What to submit
JNL considers clinical research based on its originality, timeliness, and impact on improving human health.
All aspects of clinical research are considered, including case reports and small case series, clinical trials, whether phase 1, 2, 3, or 4, observational studies, meta-analyses, biomarker studies, and studies on public and global health.
JNL has adopted the ICMJE guidelines for registering all clinical trials in manuscripts submitted to its journals.

Reporting Guidelines

• An extended CONSORT extension for N-of-1 trials must be provided for case reports or case series performed in the context of clinical trials evaluating effectiveness in a single patient if the therapy is given outside of a clinical trial. According to the CARE guidelines and in compliance with the Declaration of Helsinki principle, all research protocols must be approved by IRBs and ethics committees before publication.

• According to STROBE guidelines, observations (cohorts, case-control studies, and cross-sectional studies) must be reported.

• PRISMA guidelines must be followed when conducting systematic reviews and meta-analyses.

• The STARD guidelines should be followed for biomarker studies associated with clinical outcomes, and the REMARK guidelines should be followed for biomarker studies relating to cancer.

• GATHER recommends following the recommendations in epidemiology studies.

• The CONSORT 2010 guidelines must be followed for randomized trials, and the CONSORT checklist should be submitted along with the manuscript and other materials, including the protocol. In reporting non-randomized trials, CONSORT principles and frameworks are recommended. The CONSORT guidelines may require that reports be revised before formal review.

Registration
Prior to enrolling the first participant in an interventional trial, the trial must be registered. ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, or any publicly accessible database that meets the minimum 24-item trial registration dataset are all acceptable methods for registering trials.

• Abstracts and methods sections of manuscripts must clearly indicate the trial number.

• No trials registered retrospectively or in a database that is not publicly accessible can be considered.

Registration of Systematic Reviews
JNL encourages systematic review authors to prospectively register their systematic reviews in appropriate registries (such as PROSPERO). Those authors who have registered their systematic reviews should include the registration number in the abstracts of their manuscripts.